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GW1100

Supplier:
Catalogue number:
10-4516-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
$180.00 Shipping is calculated in checkout

GPR40 antagonist / Selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated GW9508 or linoleic acid (pIC50 = 5.99 for either agonist).1 The effects of GPR40 activation on insulin secretion in cells are also blocked by the addition of GW1100. GW1100 does not influence calcium mobilization mediated by GPR120.

Product Type:

Biochemicals & reagents

CAS Number:

306974-70-9

Reference:

1) Brisco et al. (2006), Pharmacological regulation of insulin secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist molecules; Br. J. Pharmacol., 148 619

Storage Temperature:

-20°C

Additional Information:

TARGET: GPCR -- PATHWAY: Fatty acid metabolism; ERK -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Diabetes; IschemiaPain