DJ-V 159
GPRC6A agonist; Stimulates insulin secretion in beta cells / GPRC6A is the receptor for osteocalcin as well as structurally unrelated ligands including L-amino acids, cations and anabolic steroids.1 GPRC6A is a potential therapeutic target for treating type 2 diabetes.2 DJ-V 159 is an agonist at GPRC6A which activates ERK and upregulates cAMP levels in HEK-193 cells expressing GPRC6A It stimulates insulin secretion in mouse -cells and lowers blood glucose in mouse models.3
Biochemicals & reagents
2253744-53-3
1) Pi and Quarles (2012), Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks; Endocrinology, 153 2062 2) Pi et al. (2016), GPRC6A: Jack of all metabolism (or master of none); Mol. Metab., 6 185 3) Pi et al. (2018), Computationally identified novel agonists for GPRC6A; PLoS One, 13 e0195980
RT
TARGET: GPCR -- PATHWAY: ERK; cAMP / cGMP signaling; Glucose metabolism -- DISEASE AREA: Diabetes; Obesity