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GSK-137647

Supplier:
Catalogue number:
10-1516-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
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GPR120 agonist / Potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively1. Enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR1202.

Product Type:

Biochemicals & reagents

CAS Number:

349085-82-1

Reference:

1) Martin et al. (2012), Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity; J. Lipid Res., 53 2256 2) Sparks et al. (2014), Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett., 24 3100

Storage Temperature:

-20°C

Additional Information:

TARGET: GPCR -- PATHWAY: Calcium signaling; Fatty acid metabolism -- DISEASE AREA: Diabetes