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L-755,507

Supplier:
Catalogue number:
10-4229-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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ß3 adrenergic agonist / CRISPR efficiency enhancer / L-755,507 is a very potent (EC50 = 0.43 nM; IC50 = 13 nM) human ß3 adrenergic receptor agonist with >440-fold selectivity of ß1/2.1 It elicited lipolysis and metabolic rate elevation in rhesus monkeys.2 L-755,507 has been shown to increase homology-directed repair efficiency by 2- and 3-fold in CRISPR gene editing.3,4

Product Type:

Biochemicals & reagents

CAS Number:

159182-43-1

Alternative Names:

4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]benzenesulfonamide

Reference:

1) Parmee et al. (1998), Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist; Bioorg. Med. Chem. Lett. 8 1107 2) Fisher et al. (1998), A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys; J. Clin. Invest. 101 2387 3) Li et al. (2017), Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells; Sci. Rep. 7 8943 4) Yu et al. (2015), Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells; Cell Stem Cell 16 142

Storage Temperature:

-20°C

Additional Information:

TARGET: GPCR -- PATHWAY: Fatty acid metabolism; cAMP / cGMP signaling -- RESEARCH AREA: CRISPR -- DISEASE AREA: Cancer; Obesity