L-755,507
ß3 adrenergic agonist / CRISPR efficiency enhancer / L-755,507 is a very potent (EC50 = 0.43 nM; IC50 = 13 nM) human ß3 adrenergic receptor agonist with >440-fold selectivity of ß1/2.1 It elicited lipolysis and metabolic rate elevation in rhesus monkeys.2 L-755,507 has been shown to increase homology-directed repair efficiency by 2- and 3-fold in CRISPR gene editing.3,4
Biochemicals & reagents
159182-43-1
4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]benzenesulfonamide
1) Parmee et al. (1998), Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist; Bioorg. Med. Chem. Lett. 8 1107 2) Fisher et al. (1998), A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys; J. Clin. Invest. 101 2387 3) Li et al. (2017), Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells; Sci. Rep. 7 8943 4) Yu et al. (2015), Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells; Cell Stem Cell 16 142
-20°C
TARGET: GPCR -- PATHWAY: Fatty acid metabolism; cAMP / cGMP signaling -- RESEARCH AREA: CRISPR -- DISEASE AREA: Cancer; Obesity