Lysophosphatidic acid (Oleyl form)
Endogenous LPA receptor agonist / A multifunctional intercellular bioactive phospholipid1. Stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes among others1. Acts as a proliferative and anti-apoptotic factor2. Agonist at LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors3. LPA-primed astrocytes induce axonal outgrowth of cortical progenitors4.
Biochemicals & reagents
325465-93-8
LPA · Na; 1-Oleoyl-lysophosphatidic acid, sodium salt
1) Moolenaar et al. (1995), Lysophosphatidic acid, a multifunctional phospholipid messenger; J. Biol. Chem., 270 12949 2) Levine et al. (1997), Lysophosphatidic acid; a novel growth and survival factor for renal proximal tubular cells; Am. J. Physiol., 273 F575 3) Goetzl and An (1998), Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate; FASEB J., 12 1589 4) Spohr et al. (2014), LPA-primed astrocytes induce axonal outgrowth of cortical progenitors by activating PKA signaling pathways and modulating extracellular matrix proteins; Front Cell Neurosci., 8 296
-20°C
TARGET: GPCR -- PATHWAY: Apoptosis inhibitor; Proliferation; Autophagy -- RESEARCH AREA: Neuroscience; Cell death; Stem cells -- DISEASE AREA: Cancer; Heart diseaseObesity