www.mayflowerbio.com
Sales & Support: 314-485-5210

*

Lysophosphatidic acid (Oleyl form)

Supplier:
Catalogue number:
10-1449-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
$240.00 Shipping is calculated in checkout

Endogenous LPA receptor agonist / A multifunctional intercellular bioactive phospholipid1. Stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes among others1. Acts as a proliferative and anti-apoptotic factor2. Agonist at LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors3. LPA-primed astrocytes induce axonal outgrowth of cortical progenitors4.

Product Type:

Biochemicals & reagents

CAS Number:

325465-93-8

Alternative Names:

LPA · Na; 1-Oleoyl-lysophosphatidic acid, sodium salt

Reference:

1) Moolenaar et al. (1995), Lysophosphatidic acid, a multifunctional phospholipid messenger; J. Biol. Chem., 270 12949 2) Levine et al. (1997), Lysophosphatidic acid; a novel growth and survival factor for renal proximal tubular cells; Am. J. Physiol., 273 F575 3) Goetzl and An (1998), Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate; FASEB J., 12 1589 4) Spohr et al. (2014), LPA-primed astrocytes induce axonal outgrowth of cortical progenitors by activating PKA signaling pathways and modulating extracellular matrix proteins; Front Cell Neurosci., 8 296

Storage Temperature:

-20°C

Additional Information:

TARGET: GPCR -- PATHWAY: Apoptosis inhibitor; Proliferation; Autophagy -- RESEARCH AREA: Neuroscience; Cell death; Stem cells -- DISEASE AREA: Cancer; Heart diseaseObesity