Cinacalcet HCl

Name: Cinacalcet HCl
Brand: Focus Biomolecules
SKU: 10-2957-02
Price: 100 GBP
Availability: InStock

Supplier:

Focus Biomolecules

Catalogue number:

10-2957-02

Size:

50 mg

Product is available in:

$100.00

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Calcium sensing receptor (CaSR) agonist / Cinacalcet (364782-34-3) is a calcimimetic that allosterically activates the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK 293T cells expressing CaSR).1-3 It lowers plasma parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.4 Cinacalcet has been used to treat parathyroid carcinoma.5

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Product Type:

Biochemicals & reagents

CAS Number:

364782-34-3

Alternative Names:

AMG 073; KRN 1493; Mimpara; Sensipar

Reference:

1 Filapanti et al. (2013), Pharmacology of the calcium sensing receptor; Cases Miner. Bone Metab., 10 162 2 Ma et al. (2011), Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor; Pharmacol. Exp. Ther., 337 275 3 Nemeth (2004), Calcimimetic and calcilytic drugs: just for parathyroid cells?; Cell Calcium, 35 283 4 Goodman et al. (2002), The Calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism; Am. Soc. Nephrol., 13 1017 5 Lumachi et al. (2006), Parathyroid cancer: etiology, clinical presentation and treatment; Anticancer Res., 26 4803

Storage Temperature:

-20°C

Additional Information:

TARGET: GPCR -- PATHWAY: Calcium signaling -- DISEASE AREA: Cancer