Sphingosine-1-phosphate
EDG receptor ligand / Sphingosine-1-phosphate is an endogenous sphingolipid metabolite known to be involved in many cellular responses including angiogenesis, vascular maturation, cardiac development and immunity. These effects are mediated through a family of 5 G-protein-coupled receptors.1,2,3
Biochemicals & reagents
26993-30-6
1) Spiegel and Milstien (2003) Sphingosine-1-phosphate: an enigmatic signaling lipid Nat.Rev.Mol.Cell Biol. 4 397 2) Rosen et al. (2009) Sphingosine-1-phosphate receptor signaling Annu.Rev.Biochem. 78 743 3) Maceyka et al. (2012) Sphingosine-1-phosphate signaling and its role in disease Trends Cell Biol. 22 50
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TARGET: GPCR -- PATHWAY: Sphingolipid metabolism; Apoptosis inhibitor -- RESEARCH AREA: Immunology; Angiogenesis; Cell death -- DISEASE AREA: Cancer