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CPI-444

Supplier:
Catalogue number:
10-4101-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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Adenosine A2A receptor antagonist / CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory.1,2 Currently in clinical trials for multiple cancers.3

Product Type:

Biochemicals & reagents

CAS Number:

1202402-40-1

Alternative Names:

Ciforadenant

Reference:

1) Willingham et al. (2018), A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti-PD-(L)1 and Anti-CTLA-4 in Preclinical Models; Cancer Immunol. Res. 6 1136 2) Leone et al. (2018), ), Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models; Cancer Immunol. Immunother. 671271 3) NCT02655822

Storage Temperature:

-20°C

Additional Information:

TARGET: GPCR -- PATHWAY: cAMP / cGMP signaling -- RESEARCH AREA: Immunology -- DISEASE AREA: Cancer