Latrunculin A
Inhibits actin polymerization and microfilament organization / Inhibits actin polymerization and disrupts microfilament organization1. Significantly more potent than cytochalasins in the disruption of microfilamament mediated processes.2 Active in cell culture.3,4
Biochemicals & reagents
76343-93-6
1) Coue et al. (1987), Inhibition of actin polymerization by latrunculin; FEBS Lett., 213 316 2) Spector et al. (1989), Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth; Cell Motil. Cytoskeleton, 13 127 3) Wang et al. (2005), Differential effects of latrunculin-A on myofibrils in cultures of skeletal muscle cells: Insights into mechanisms of myofibrillogenesis; Cell Motil. Cytoskeleton, 62 35 4) Reggiori et al. (2005), The actin cytoskeleton is required for selective types of autophagy, but not for non-specific autophagy, in the yeast Saccharomyces cerevisiae; Mol. Biol. Cell, 16 5843
-20°C
TARGET: Cytoskeleton -- PATHWAY: Cell cycle