Forchlorfenuron
Inhibits septin dynamics / Reversibly perturbs mammalian septin assembly, organization and function. Has no effect on actin or tubulin polymerization.1,2 FCF induces effects on mitosis and migration which phenocopy the effects induced by septin depletion using siRNA1. A useful tool for exploring the physiological role of septin and its complexes.3,4
Biochemicals & reagents
68157-60-8
FCF; KT-30; CPPU
1) Hu et al. (2008), Forchlorfenuron alters mammalian septin assembly, organization, and dynamics; J. Biol. Chem., 283 29563 2) DeMay et al. (2010), Cellular requirements for the small molecule forchlorfenuron to stabilize the septin cytoskeleton; Cytoskeleton, 67 383 3) Wasik et al. (2012), Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking; Mol. Biol. Cell, 23 3370 4) Vardi-Oknin et al. (2013), Forchlorfenuron disrupts SEPT9_i1 filaments and inhibits HIF-1; PLoS One, 8(8) e73179
-20°C
TARGET: Cytoskeleton -- PATHWAY: Cell cycle; Cell migration