BO-264
TACCS inhibitor / BO-264 is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26.
Biochemicals & reagents
2408648-20-2
1) Akbulut et al. (2020), A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate; Mol. Cancer Ther. 19 11243
-20°C
TARGET: Cytoskeleton -- PATHWAY: Intracellular transport; Cell cycle; Proliferation; NFkappaB; Cell migration -- DISEASE AREA: Cancer