IWR-1 endo
Wnt signaling inhibitor / A potent inhibitor of Wnt signaling (IC50=180 nM).1 Inhibits zebrafish tailfin regeneration (0.5 mM).2 Acts via inhibition of tankyrase and attenuates Wnt/b-catenin signaling in cancer stem-like cells.3 Promotes self-renewal and maintains pluripotency of human embryonic stem cells.4 Promotes differentiation of pluripotent stem cells into cardiomyocytes.5
Biochemicals & reagents
1127442-82-3
1) Chen et al. (2009), Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer; Nature Chem. Biol.., 5 100 2) Lu et al. (2009), Structure-activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response; Biorg. Med. Chem. Lett., 19 3825 3) Martins-Neves et al. (2018), IWR-1, a tankyrase inhibitor, attenuates Wnt/ß-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of subcutaneous human osteoxsarcoma xenograft; Cancer Lett., 414 1 4) Kim et al. (2013), Modulations of ß-catenin function matains mouse epiblast stem cell and human embryonic stem cell self-renewal; Nature Commun., 4 4403 5) Ren et al. (2011), Small Molecule Wnt Inhibitors Enhance the Efficiency of BMP-4-directed Cardiac Differentiation of Human Pluripotent Stem Cells; J. Mol. Cell. Cardiol., 51 280
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TARGET: Cytoskeleton -- PATHWAY: Wnt; GSK3 -- RESEARCH AREA: Stem cells -- DISEASE AREA: Cancer