Dynarrestin
Cytoplasmic dynein 1/2 inhibitor / Dynarrestin is a reversible inhibitor of cytoplasmic dyneins 1 and 2.1 It inhibits dynein 1-dependent microtubule binding and motility without affecting ATP hydrolysis as well as dynein 2-dependent intraflagellar transport of the cargo IFT88 and flux of Smoothened within cilia without interfering with ciliogenesis. Dynarrestin suppresses hedgehog-dependent proliferation of neuronal precursors and tumor cells. It binds protein tyrosine phosphatase interacting protein 51 (PTPIP51) leading to increased MAPK activation and complete blockade of Akt signaling in Her2 positive breast cancer cells (SKBR3).2
Biochemicals & reagents
2222768-84-3
LDC3
1) Höing et al. (2018) Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein; Cell Chem. Biol. 25 357 2) Dietel et al. (2019) Crosstalks of the PTPIP51 interactome revealed in Her2 amplified breast cancer cells by the novel small molecule LDC3/Dynarrestin; PLoS One 14 e0216642
-20°C
TARGET: Cytoskeleton -- PATHWAY: MAPK; AKT; Hedgehog; Intracellular transport -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Cancer; Neurodegeneration