Nocardamine
Natural product siderophore / Nocardamine is a bacterially produced siderophore1 which can act as an intracellular ion chelator2. A cyclic analog of the ferroptosis inhibiting siderophore deferoxamine.3 Displayed inhibitory effects to colony formation of T-47D, SK-Mel-5, SK-Mel-28 and PRMI-7951 tumor cell lines4 as well as antimalarial activity5.
Biochemicals & reagents
26605-16-3
Desferrioxamine E; Nocardamin
1 Normant et al. (2020), Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter; ACS Chem. Biol. 15 2741 2 Ueki et al. (2009), Nocardamin Production by Streptomyces avermitilis; Actinomycetologica 23 34 3 Yan et al. (2021), Ferroptosis: mechanisms and links with diseases; Signal Transduct. Target Ther. 6 49 4 Kalinovskaya et al. (2011), Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity; Res. 166 654 5 Mahmud et al. (2022), Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809; Molecules 27 2292
-20°C
TARGET: Chelator -- PATHWAY: Ferroptosis -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer; Infectious disease