Lipoic acid (DL, α)
Endogenous antioxidant and cofactor / Endogenous antioxidant.1,2 Treatment with alpha-lipoic acid increased hepatic nuclear Nrf2 levels, induced Nrf2-mediated gene transcription, and reversed age-related decline in hepatic glutathione levels in a rat model.3 It is an essential cofactor required for catalysis by multiple mitochondrial enzymes including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase and branched-chain ketoacid dehydrogenase among others.4 It has shown efficacy as a treatment in diabetic neuropathy.5
Biochemicals & reagents
1077-28-7
Thioctic acid
1 Packer et al. (1995), alpha-Lipoic acid as a biological antioxidant; Free Radic. Biol. Med., 19 227 2 Shay et al. (2008), α-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant activity; IUBMB Life, 60 362 3 Suh et al. (2004), Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid; Proc. Natl. Acad. Sci. USA, 101 3381 4 Solmonson and DeBerardinis (2018), Lipoic acid metabolism and mitochondrial redox regulation; J. Biol. Chem., 293 7522 5 Papanas and Ziegler (2014), Efficacy of α-lipoic acid in diabetic neuropathy; Expert Opin. Pharmacother., 15 2721
-20°C
TARGET: Antioxidant -- PATHWAY: Redox; Mitochondrial function -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Diabetes; CancerObesity