Doxycycline monohydrate
Broad spectrum antibiotic / Doxycycline monohydrate is a broad-spectrum tetracycline antibiotic.1 Inhibits matrix metalloproteases.2 Promotes wound repair by inhibiting collagen degradation in rat models.3 Displays neuroprotective effects in neurodegenerative diseases.4 Frequently used in doxycycline-controlled transcriptional activation systems for regulation of gene expression in cell culture and organisms.5,6
Biochemicals & reagents
17086-28-1
1 Riond and Riviere (1988), Pharmacology and toxicology of doxycycline; Vet. Hum. Toxicol. 30 431 2 Smith et al. (1999), Specificity of inhibition of matrix metalloproteinase activity by doxycycline: Relationship to structure of the enzyme; Arthritis Rheum. 42 1140 3 Lamparter et al. (2002), Doxycycline and tissue repair in rats; J. Lab. Clin. Med. 139 295 4 Santa-Cecilia et al. (2019), The Neuroprotective Effect of Doxycycline on Neurodegenerative Diseases; Neurotox. Res. 35 981 5 Gossin et al. (1995), Transcriptional activation by tetracyclines in mammalian cells; Science 268 1766 6 Li et al. (2013), Simple piggyBac transposon-based mammalian cell expression system for inducible protein production; Proc. Natl. Acad. Sci. USA 110 5004
-20°C
TARGET: Antibiotic -- PATHWAY: Protein synthesis -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration