N-Acetylcysteine ethyl ester
Cell permeable antioxidant / N-Acetylcysteine ethyl ester is a lipophilic, cell permeable ethyl ester derivative of N-acetylcysteine.1 In oxidative stressed retinal pigment epithelial (RPE) cells NACET increases viability more efficiently than NAC and pretreatment predisposes RPE cells to oxidative stress resistance.1 Enhances intracellular glutathione concentration in HUVECs.2 Acts as a potent protector against hydroperoxide-induced oxidative damage.3 Protects against UV-induced reactive intermediates in human keratinocytes.4
Biochemicals & reagents
59587-09-6
(R)-Ethyl 2-acetamido-3-mercaptopropanoate; NACET; NAC ethyl ester
1 Tosi et al. (2021), Superior Properties of N-Acetylcyteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage; Int. J. Mol. Sci. 22 600 2 Giustarini et al. (2018), N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs; Free Radic. Biol. Med. 126 202 3 Giustarini et al. (2012), N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential; Biochem. Pharmacol. 84 1522 4 Steenvoorden et al. (1997), Cysteine derivatives protect against UV-inducede reactive intermediates in human keratinocytes: the role of glutathione synthesis; Photochem. Photobiol. 66 665
-20°C
TARGET: Antioxidant -- PATHWAY: Redox -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Inflammation