Tf2 is a potent Nav1.3 activator. Tf2 was originally isolated from the venom of the Brazilian scorpion Tityus fasciolatus. This β-scorpion peptide toxin has been described potently potentiate Nav1.3 opening at 1µm without affecting other Nav isorforms.
Peptides & proteins
Camargos T., et al. (2015) doi: 10.1371/journal.pone.0128578 , PMID: 26083731
AA Sequence: KEGYAMDHEGCKFSCFIRPSGFCDGYCKTHLKASSGYCAWPACYCYGVPSNIKVWDYATNKC-NH2. Disulfide bonds between Cys1-Cys8, Cys2-Cys5, Cys3-Cys6 and Cys4-Cys7.