StemRegenin 1 is an AhR inhibitor. StemRegenin 1 induces CD34+ cell expansion by binding and antagonizing AhR. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells. Sequential co-culture with BMP-4, PGE2, and StemRegenin 1 leads to robust Macaca nemestrina iPSC hematopoietic progenitor cell formation. Culture of mPB CD34+ cells with cytokines plus StemRegenin 1 increases the number of CD34+, CD133+ and CD90+ hematopoietic stem and progenitor cell populations compared to control cells. StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells.
Peptides & proteins
1) Gao, H., et al. 2012. J Biol Chem. 287(35): 29979-29987. PMID: 22791709; 2) Gori, JL., et al. 2012. Blood. 120(13): e35-44. PMID: 22898598; 3) Thordardottir, S., et al. 2014. Stem Cells Dev. 23(9): 955-967. PMID: 24325394
-20°C. Keep away from direct sunlight.
12 months from receipt