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Sorafenib

Sorafenib
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Size: 50 mg
$155.00
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Catalogue number:
SM95-50
Name:
Sorafenib
Supplier:
Availability:

Sorafenib is a multikinase inhibitor with activity against Raf kinase and several receptor tyrosine kinases, including vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit. It suppresses ERK phosphorylation. It also induces the phosphorylation of PKA. Sorafenib has anti-tumor activity in HCC models may be attributed to inhibition of tumor angiogenesis (VEGFR and PDGFR) and direct effects on tumor cell proliferation/survival (Raf kinase signaling-dependent and signaling-independent mechanisms).

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
284461-73-0
Alternative Names:
Bay 43-9006, Nexavar, 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-Nmethyl-pyridine-2-carboxamide
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
464.82
Material Safety Data Sheet:
Reference:
1) Liu, L., et al. 2006. Cancer Res. 66(24): 11851-11858. PMID: 17178882; 2) Aleman, JO., et al. 2014. Endocr Relat Cancer. 21(3): R247-259. PMID: 24478055; 3) Wurth, R., et al. Biomed Res Int. 2014: 126586. PMID: 24527434
Shelf Life:
12 months from receipt