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SAHA

SAHA
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Size: 1 g
$520.00
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Catalogue number:
SM88-1000
Name:
SAHA
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SAHA (suberoylanilide hydroxamic acid) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs. Experiments suggest that SAHA causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. SAHA alters gene transcription and induces cell cycle arrest and/or apoptosis in a wide variety of transformed cells. It suppresses cell growth in a range of cancer cell lines, induces apoptosis in cutaneous T-cell lymphoma cells in-vitro. This small molecule improves reprogramming efficiency after transduction of iPSC transcription factors in mouse embryonic fibroblasts.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
149647-78-9
Alternative Names:
MK-0683, Vorinostat, Suberoylanilide Hydroxamic Acid,Suberanilohydroxamic Acid, Zolinza, N-HydroxyN'-phenyloctanediamide
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
264.32
Material Safety Data Sheet:
Reference:
1) Butler, LM., et al. 2000. Cancer Res. 60(18): 5165-5170. PMID: 11016644; 2) Huangfu, D., et al. 2008. Nat Biotechnol. 26(7): 795-797. PMID: 18568017; 3) Zhang, Y., et al. 2012. J Cell Sci. 125(Pt 23): 5609-5620. PMID: 23420199; 4) Ma, T., et al. 2013. Circ Res. 112(3): 562-574. PMID: 23371904
Shelf Life:
12 months from receipt