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Ruxolitinib

Catalogue number:
SM87-2
Size:
2 mg
Product is available in:
  • USA
  • Canada
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Ruxolitinib is a JAK inhibitor of JAK1, JAK2, and JAK3. JAKs, or Janus-associated kinases, are tyrosine kinases found in the cytoplasm that are known to active the signaling of certain growth factor receptors and cytokines. JAK inhibition with ruxolitinib could work as pretreatment for allogeneic stem cell transplantation in myelofibrosis. Ruxolitinib inhibits erythropoiesis from induced pluripotent stem cells (iPSC), but has less inhibitory effect on the self-renewal of CD34+ hematopoietic progenitors.

Product Type:

Peptides & proteins

CAS Number:

941678-49-5

Alternative Names:

INCB018424, INCB18424, NCB018424, NCB18424, (3R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1Hpyrazol-1-yl)-3-cyclopentylpropanenitrile

Range:

1) Stübig, T., et al. 2014. Leukemia. PMID: 24569777; 2) Ye, Z., et al. 2014. Stem Cells. 32(1): 269-278. PMID: 24105986

Limit of Detection:

306.37

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt