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NVP-BEZ235

NVP-BEZ235
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Size: 25 mg
$55.00
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Catalogue number:
SM69-25
Name:
NVP-BEZ235
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Availability:

NVP-BEZ235 is a PI 3-kinase (PI3K) tyrosine kinase inhibitor and shows dual PI3K/mTOR inhibition. NVP-BEZ235 also inhibits ATR. However, NVP-BEZ235 has been shown to be poor inhibitory to Akt and PDK1. NVP-BEZ235 shows high target specificity and demonstrates antiproliferative activity against tumor cell lines in animal models of cancer.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
915019-65-7
Alternative Names:
BEZ235, Dactolisib, 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
469.54
Material Safety Data Sheet:
Reference:
1) Lyssiotis, CA., et al. 2011. Angew Chem Int Ed Engl. 50(1): 200-242. PMID: 21184400; 2) Wang, WJ., et al. 2013. Acta Pharmacol Sin. 34(5): 681-690. PMID: 23603977
Shelf Life:
12 months from receipt