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GX15-070

Catalogue number:
SM56-10
Size:
10 mg
Product is available in:
  • USA
  • Canada
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GX15-070 is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl-2 and thus inducing apoptosis. GX15-070 enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. GX15-070 potentiates TRAIL-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells.

Product Type:

Peptides & proteins

CAS Number:

803712-79-0

Alternative Names:

Obatoclax, GX15-070MS, (Z)-2-(5-((3,5-dimethyl-1Hpyrrol-2-yl)methylene)-4-methoxy-5H-pyrrol-2-yl)-1Hindole mesylate

Range:

1) Konopleva, M., et al. 2008, Cancer Research. 68(9): 3413-3420. PMID: 18451169; 2) Fan, W., et al. 2011. Cancer Res. 71(13): 4494-4505. PMID: 21555370; 3) Ying, S., et al. 2012. Cancer Res. 72(11): 2814-2821. PMID: 22447567

Limit of Detection:

413.49

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt