GX15-070
Supplier:
Catalogue number:
SM56-10
Size:
10 mg
Product is available in:
GX15-070 is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl-2 and thus inducing apoptosis. GX15-070 enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. GX15-070 potentiates TRAIL-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells.
Product Type:
Peptides & proteins
CAS Number:
803712-79-0
Alternative Names:
Obatoclax, GX15-070MS, (Z)-2-(5-((3,5-dimethyl-1Hpyrrol-2-yl)methylene)-4-methoxy-5H-pyrrol-2-yl)-1Hindole mesylate