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Tandutinib

Catalogue number:
SM102-50
Size:
50 mg
Product is available in:
  • USA
  • Canada
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Tandutinib is a piperazinyl quinazoline receptor tyrosine kinase inhibitor. Tandutinib inhibits the autophosphorylation of Flt-3/Flk-2 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases. Tandutinib is an inhibitor of PDGFR-β. Tandutinib inhibits cellular proliferation and induces apoptosis. Tandutinib works as a stem-like cells targeted agent to increase efficiency of anticancer drugs and it has antineoplastic activity.

Product Type:

Peptides & proteins

CAS Number:

387867-13-2

Alternative Names:

MLN518, CT53518, D06005, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide

Range:

1) Griswold, IJ., et al. 2004. Blood. 104(9): 2912-2918. PMID: 15242881; 2) Brownlow, N., et al. 2008. Leukemia. 22(7): 1452-1453. PMID: 18185521; 3) Zhao, XQ., et al. 2013. Eur J Pharm Sci. 49(3): 441-450. PMID: 23619284

Limit of Detection:

562.7

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt