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Sunitinib

Catalogue number:
SM101-10
Size:
10 mg
Product is available in:
  • USA
  • Canada
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Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFR beta. It also inhibits c-Kit. Sunitinib inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Sunitinib has been shown to impinge on the osteoblast differentiation process in-vitro. It exhibits antiangiogenic and antitumor activity in multiple xenograft models.

Product Type:

Peptides & proteins

CAS Number:

557795-19-4

Alternative Names:

SU-11248, Sutent, PHA-290940AD, PNU-290940AD, N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

Range:

1) Hersey, P., et al. 2009. Ann Oncol. 20 Suppl 6: vi35-40. PMID: 19617296; 2) Fernandez-Fuente, G., et al. 2014. Mol Cancer Ther. PMID: 24723451; 3) Alemán, JO., et al. 2014. Endocr Relat Cancer. 21(3): R247-59. PMID: 24478055

Limit of Detection:

398.47

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt