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ALK5 Inhibitor II

Catalogue number:
SM09-25
Size:
25 mg
Product is available in:
  • USA
  • Canada
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ALK5 Inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50 = 23 nM, 4 nM and 18 nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). TGF-β RI (ALK5) Inhibitor II affects a panel of 9 closely related kinases including p38 MAPK. ALK5 can replace Sox2 for generation of induced pluripotent stem cells (iPSC).

Product Type:

Peptides & proteins

CAS Number:

446859-33-2

Alternative Names:

2-(3-(6-methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

Range:

1) Gellibert, F., et al. 2004. J Med Chem 47: 4494-4506. PMID: 15317461; 2) Ichida, J.K., et al. 2009. Cell Stem Cell 5: 491-503. PMID: 19818703

Limit of Detection:

287.32

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt