Growth and Differentiation Factor 15 (GDF-15) is a TGF beta family member, made by the placenta and heart tissues, that has a role in regulating inflammatory and apoptotic pathways. GDF-15 has become an emerging marker of early heart disease and has the potential of being used as a molecule for screening patients for early heart failure. Recombinant human GDF-15 D is a non-glycosylated, disulfide linked homodimer. There is a His to an Asp substitution at position 7.
Peptides & proteins
MIC-1, Placental TGFβ, Prostate differentiation factor
NAME: Growth and Differentiation Factor-15 D; ACCESSION/UNIPROT#: Q99988; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA). Reconstitute in sterile water at 0.1 mg/mL.; #AA: 226; SEQUENCE: MARNGDDCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI