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Rho-conotoxin TIA

Catalogue number:
CON022-01000
Size:
1 mg
Product is available in:
  • USA
  • Canada
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Rho-conotoxin TIA has been isolated from the venom of the fish-hunting marine cone snail Conus tulipa. Rho-conotoxin TIA is a selective antagonist of α1-adrenoreceptor (α1A-, α1B- and α1D-AR). It acts non-competitively onto α1B-adrenoreceptor but competitively on α1A-adrenoreceptor and α1D-adrenoreceptor. The most important residue for activity is Arg4. Rho-conotoxin TIA is 10-fold selective for human α1B-adrenoreceptor over α1A-adrenoreceptor and α1D-adrenoreceptor. The IC50 values for Rho-conotoxin TIA for inhibition of 125I-BE were 18 nM for human α1A-AR, 2 nM for α1B-AR and 25 nM for α1D-AR.

  • Applications:TARGET CLASS: GPCR; TARGET: a1-adrenoreceptor; ACTION: Blocker
Product Type:

Peptides & proteins

Limit of Detection:

2390.90 Da

Storage Temperature:

RT

Additional Information:

AA SEQUENCE: Phe-Asn-Trp-Arg-Cys5-Cys6-Leu-Ile-Pro-Ala-Cys11-Arg-Arg-Asn-His-Lys-Lys-Phe-Cys19-NH2; DISULFIDE BONDS: Cys5-Cys11 and Cys6-Cys19; SOURCE: Synthetic; PURITY: > 95%

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