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Huwentoxin-XVI

Catalogue number:
HWT016-01000
Size:
1000 µg
Product is available in:
  • USA
  • Canada
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Huwentoxin-XVI is a selective blocker of N-type Ca2+ channels. Huwentoxin-XVI is a 39 amino acids peptide that was discovered from the venom of the Chinese tarantula Ornithoctonus huwena. Huwentoxin-XVI was shown to be a potent blocker of HVA N-type calcium channels with an IC50 value of 60 nM in rat DRG. The blocking effect appears to be similar to that of ω-conotoxin-GVIA and ω-conotoxin-MVIIA. Neverthelss, Huwentoxin-XVI differs from GVIA and MVIIA thanks to its greater reversibility and its higher selectivity for N-type over P/Q type than MVIIA.

  • Applications:Calcium channel blocker
Product Type:

Peptides & proteins

Reference:

Deng M., et al. (2014) Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonus huwena. Neuropharmacol.

Storage Temperature:

Stable at room temperature under lyophilized powder. Store at -20°C for long term storage over 2 mon

Additional Information:

AA sequence: Cys1-Ile-Gly-Glu-Gly-Val-Pro-Cys8-Asp-Glu-Asn-Asp-Pro-Arg-Cys15-Cys16-Ser-Gly-Leu-Val-Cys21-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp-Tyr-Lys-Ser-Tyr-Tyr-Cys36-Tyr-Lys-Lys-OH; Disulfide bonds: Cys1-Cys16, Cys8-Cys21 and Cys15-Cys36

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