TH257
Supplier:
Catalogue number:
10-4418-02
Size:
25 mg
Product is available in:
Allosteric LIM kinase inhibitor / TH257 is a potent (IC50’s = 238 nM (LIMK1) and 91 nM (LIMK2)) and highly selective (no off-targets against 468 kinases) allosteric inhibitor of LIM kinase 1/2.1 It inhibited neurite outgrowth in N1E-115 cells in a dose-dependent manner.
Product Type:
Biochemicals & reagents
CAS Number:
2244678-29-1
Reference:
Hanke et al. (2022) Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes; J. Med. Chem. 65 13264
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- PATHWAY: Proliferation; Cytoskeleton -- RESEARCH AREA: Neuroscience