SC-79
AKT activator / Akt activator. Binds to the pleckstrin homology domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo.1 A useful tool for studying the PI3K/Akt axis.2
Biochemicals & reagents
305834-79-1
1) Jo et al. (2012), Small-molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death; Proc. Natl. Acad. Sci. USA, 109 10581 2) Yang et al. (2016), MiR-221 Promotes Capan-2 Pancreatic Ductal Adenocarcinoma Cells Proliferation by Targeting PTEN-Akt; Cell. Physiol. Biochem., 38 2366 3) Chen et al. (2017), Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head; Oncotarget; 8 31065
-20°C
TARGET: Kinase -- PATHWAY: PI3K; AKT -- RESEARCH AREA: Neuroscience