(5Z)-7-Oxozeaenol
TAK1 inhibitor / Potent and selective inhibitor of TAK1 (mitogen activated protein kinase kinase kinase) IC50 = 8 nM.1 Selective over MEKK1 and MEKK4. Blocks IL-1-induced activation of TAK1 in cell culture.1 Blocks the production of pro-inflammatory cytokines and displays anti-inflammatory activity in various models.2-4
Biochemicals & reagents
253863-19-3
1 Ninomiya-Tsuji et al. (2003), A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase; J. Biol. Chem., 278 18485 2 Windheim et al. (2007), Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide; Biochem. J., 404 179 3 Xu et al. (2016), Blockade of TGF-ß-activated kinase 1 prevents advanced glycation end products-induced inflammatory response in macrophages; Cytokine, 78 62 4 Ivshina et al. (2015), CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response; Mol. Cell. Biol., 35 610
-20°C
TARGET: Kinase -- PATHWAY: TGF-beta; Cytokine -- RESEARCH AREA: Immunology -- DISEASE AREA: Inflammation