JNK3 inhibitor / JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppresive activity. Inhibits LPS-induced proinflammatory cytokine and nitric oxide release in vitro.1 Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo.2
Biochemicals & reagents
1421610-21-0
1) Schepetkin et al. (2012), Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors; Mol. Pharmacol., 81 832 2) Schepetkin et al. (2015), Anti-Inflammatory effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1A, a Selective c-Jun N-Terminal Kinase Inhibitor; J. Pharmacol. Exp. Ther., 353 505
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TARGET: Kinase -- PATHWAY: Cytokine; JNK pathway -- RESEARCH AREA: Immunology -- DISEASE AREA: Inflammation