Gilteritinib
Supplier:
Catalogue number:
10-4170-01
Size:
5 mg
Product is available in:
FLT3 inhibitor / Potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants.1 It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters.2
Product Type:
Biochemicals & reagents
CAS Number:
1254053-43-4
Alternative Names:
ASP2215
Reference:
Lee et al. (2017) Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor; Blood 129 257 Thomas et al. (2021) Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT-3-ITD-Positive AML; Cancer Ther. 20 2207
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- PATHWAY: Proliferation; Amino acid metabolism -- DISEASE AREA: Cancer