SNS-314 mesylate
Aurora kinase inhibitor / SNS-314 is a potent and selective pan-Aurora kinase inhibitor (IC50’s: Aurora A = 9 nM, Aurora B = 31 nM, Aurora C = 3 nM.1,2 It was able to inhibit proliferation in a wide panel of human cancer cell lines including colon (HCT116), breast (MDA-MB-231), prostate (PC-3), lung (H1299, Calu-6), ovarian (A2780), melanoma (A375) and liver (SMMC-7721, HepG2, LM6).1-4
Biochemicals & reagents
1146618-41-8
1) Oslob et al. (2008) Discovery of a potent and selective aurora kinase inhibitor; Bioorg. Med. Chem. Lett. 18 4880 2) Arbitrario et al. (2010) SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo; Cancer Chemother. Pharmacol. 65 707 3) VanderPorten et al. (2009) The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model; Mol. Cancer Ther. 8 930 4) Liu et al. (2017) Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma; Oncotarget 8 27953
-20°C
TARGET: Kinase -- PATHWAY: Proliferation -- DISEASE AREA: Cancer