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Lapatinib (base)

Supplier:
Catalogue number:
10-2147-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
$55.00 Shipping is calculated in checkout

EGFR and HER2 inhibitor / Potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM)1. Clinically useful agent for treatment of breast cancer2-3. Cell permeable

Product Type:

Biochemicals & reagents

CAS Number:

231277-92-2

Alternative Names:

GW-572016

Reference:

1) Wood et al. (2004), A unique structure for epidermal growth fsctor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells; Cancer Res., 64 6652 2) Burris et al. (2004), Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib; Oncologist, 9 10 3) Chu et al. (2005), The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016) cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer; Cancer Res., 65 18

Storage Temperature:

-20°C

Additional Information:

TARGET: Kinase -- PATHWAY: Estrogen -- DISEASE AREA: Cancer