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AG 1478 (Base)

Supplier:
Catalogue number:
10-2117-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
$150.00 Shipping is calculated in checkout

EGFR kinase inhibitor / Potent and selective inhibitor of the EGFR kinase IC50 = 3 nM. Inhibits proliferation of a variety human cancer cell lines1,2. Reduces pulmonary fibrosis in a rat model3. Cell permeable.

Product Type:

Biochemicals & reagents

CAS Number:

175178-82-2

Reference:

1) Han et al. (1996), Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors; Cancer Res., 56 3859 2) Partik et al. (1999), Inhibition of epidermal-growth-factor-receptor-dependent signaling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro; J. Cancer Res. Clin. Oncol., 125 379 3) Rice et al. (1999), Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats; Am. J. Pathol., 155 213

Storage Temperature:

-20°C

Additional Information:

TARGET: Kinase -- PATHWAY: EGF; Proliferation -- DISEASE AREA: Cancer