Casein kinase 2 inhibitor / Potent inhibitor of casein kinase 2 (CK2; IC50 = 7 nM).1 Showed no inhibition of DYRK, HIPK, CLK, and PIM family kinases. It is a circadian clock modifier that caused strong period lengthening. Growth of MLL-AF9 leukemia cells was strongly inhibited by GO289.
Product Type:
Biochemicals & reagents
CAS Number:
694522-87-7
Reference:
1) Oshima et al. (2019), Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth; Sci. Adv. 5 eauu9060
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- RESEARCH AREA: Circadian clock -- DISEASE AREA: Cancer