3-Methyladenine
Autophagosome inhibitor / Inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and hydroxyphenazine-induced toxicity3. Enhances celastrol-induced apoptosis in human pancreatic cancer cells4.
Biochemicals & reagents
5142-23-4
3-MA
1) Seglen and Gordon et al. (1982), 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes; Proc. Natl. Acad. Sci. USA, 79 1889 2) Blommaart et al. (1997), The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem., 243 240 3) McFarland et al. (2012), Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity; Arch. Toxicol., 86 275 4) Zhao et al. (2014), Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models; Curr. Mol. Med., 14 555
-20°C
TARGET: Kinase -- PATHWAY: Autophagy; PI3K; Apoptosis inducer -- RESEARCH AREA: Cell death; Vesicles -- DISEASE AREA: Cancer