Deguelin
Akt inhibitor / Inhibits Akt1,2. Induces apoptosis in a variety of cells2,3. Displays cancer chemopreventive activity4. Cell permeable. Active in vivo.
Biochemicals & reagents
522-17-8
1) Chun et al. (2003), Effects of deguelin on the phosphatidylinositol 3- kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells; J. Natl. Cancer Inst., 95 291 / 2) Kang et al. (2012), Deguelin, an AKT Inhibitor, Down-Regulates NFκB Signaling and Induces Apoptosis in Colon Cancer Cells and Inhibits Tumor Growth in Mice; Dig. Dis. Sci., May 24 (Epub) / 3) Lee et al. (2004), Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells; Biochem. Pharmacol., 68 1119 / 4) Ito et al. (2004), Cancer chemopreventive activity of rotenoids from Derris trifoliata; Planta Med., 70 8
RT
TARGET: Kinase -- PATHWAY: AKT; Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer