2GBI
Hv1 channel blocker / A selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3 Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4
Biochemicals & reagents
5418-95-1
1) Hong et al. (2015), Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep., 5 14077 2) Hong et al. (2014), Molecular deterinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA, 111 9971 3) Gianti et al. (2016), On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA, 113 E8359 4) Pupo and Gonzalez (2014), In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA, 111 9673
RT
TARGET: Ion channel -- PATHWAY: Proton channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Cancer; InflammationNeurodegeneration