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Evodiamine

Supplier:
Catalogue number:
10-2336-01
Size:
50 mg
Product is available in:
  • USA
  • Canada
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TRPV1 agonist, antiinflamatory, antiangiogenic / Evodiamine is a quinolone alkaloid isolated from Evodia rutaecarpa.1 Evodia Rutaecarpa is a very popular herb used in traditional chinese medicine to treat a variety of ailments. It has been shown to elicit a variety of biological effects including induction of apoptosis, inhibiting cancer cell proliferation, promoting cell cycle arrest in G2/M, inhibiting invasion and metastasis of cancer cells, inhibiting angiogenesis, induction of oxidative stress and subsequent apoptosis and inhibition of NF-κB.2 It also functions as an agonist of TRPV1 (EC50 = 1.03 µM)3 and acts as an anti-inflammatory agent4.

Product Type:

Biochemicals & reagents

CAS Number:

518-17-2

Reference:

1) Shoji et al. (1986) Isolation of evodiamine, a powerful cardiotonic principle, from Evodia Rutaecarpa Bentham (Rutaceae) J. Pharm. Sci. 75 612 2) Jiang and Hu et al. (2009) Evodiamine: A novel anti-cancer alkaloid from Evodia rutaecarpa. Molecules 14 1852 3) Pearce et al. (2004) Evodiamine functions as an agonist for the vanilloid receptor Org. Biomol. Chem. 2 2281 4) Choi et al. (2006) Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms Arch. Pharm. Res. 29 293

Storage Temperature:

-20°C

Additional Information:

TARGET: Ion channel -- PATHWAY: Cation channel; Cell cycle; NFkappaB; Proliferation; Apoptosis inducer; Cytokine -- RESEARCH AREA: Cell death; Oxidative stress; Angiogenesis; Neuroscience -- DISEASE AREA: Cancer; Inflammation