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TRO19622

Supplier:
Catalogue number:
10-3230-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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Neurotrophic agent / Neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1 Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2 Inhibits MPTP opening and protects neurons from apoptosis.3 Induces oligodendrocyte maturation in culture and promotes myelin regeneration in vivo in a rodent model.4

Product Type:

Biochemicals & reagents

CAS Number:

22033-87-0

Alternative Names:

Olesoxime

Reference:

1) Bordet et al. (2007), Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis; J. Pharmacol. Exp. Ther., 322 709 2) Ma et al. (2014), NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage; Ann. Neurol., 75 209 3) Martin et al. (2011), The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation; J. Neurosci., 31 359 4) Magalon et al. (2016), Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules; Neuropharmacology, 111 293

Storage Temperature:

-20°C

Additional Information:

TARGET: Inflammasome -- PATHWAY: Neurotrophin; Mitochondrial function; Apoptosis inhibitor -- RESEARCH AREA: Neuroscience; Oxidative stress; Cell death; Immunology -- DISEASE AREA: Neurodegeneration