TRO19622
Neurotrophic agent / Neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1 Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2 Inhibits MPTP opening and protects neurons from apoptosis.3 Induces oligodendrocyte maturation in culture and promotes myelin regeneration in vivo in a rodent model.4
Biochemicals & reagents
22033-87-0
Olesoxime
1) Bordet et al. (2007), Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis; J. Pharmacol. Exp. Ther., 322 709 2) Ma et al. (2014), NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage; Ann. Neurol., 75 209 3) Martin et al. (2011), The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation; J. Neurosci., 31 359 4) Magalon et al. (2016), Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules; Neuropharmacology, 111 293
-20°C
TARGET: Inflammasome -- PATHWAY: Neurotrophin; Mitochondrial function; Apoptosis inhibitor -- RESEARCH AREA: Neuroscience; Oxidative stress; Cell death; Immunology -- DISEASE AREA: Neurodegeneration