Urolithin A
Mitophagy inducer / Microbial metabolite of dietary ellagitannins produced in the gut.1 It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents.2 It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinson’s disease model.3 The pro-mitophagy activity of UA may be beneficial in Alzheimer’s disease.4 Ex vivo UA-treated T cells display improved anti-tumor function.5
Biochemicals & reagents
1143-70-0
1 Gonzalez-Barrio et al. (2011), UV and MS identification of Urolithins and Nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals; J. Agric.Food Chem., 59 1152 2 Ryu et al. (2016), Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents; Nat. Med. 22 8798 3 Qiu et al. (2022), Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson’s disease model; Neuropharmacology, 207 108963 4 Jayatunga et al. (2021), Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease; Nutrients, 13 3744 5 Denk et al. (2022), Expansion of T memory cells with superior anti-tumor immunity by Urolithin A mitophagy; Immunity, 55 2059
-20°C
TARGET: Inflammasome -- PATHWAY: Mitophagy; Senescence -- RESEARCH AREA: Immunology; Stem cells; Oxidative stress -- DISEASE AREA: Inflammation; NeurodegenerationCancer; Ageing