Pifithrin mu
Hsp70 inhibitor / Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. Inhibits p53 binding to antiapoptotic proteins Bcl-xL and Bcl-2. Recues primary mouse thymocytes from P53-mediated apoptosis induced by radiation. Cell permeable.
Biochemicals & reagents
64984-31-2
PES; NSC-303580
1) Leu et al. (2009), The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53.; Mol. Cell, 36 15. / 2) Strom et al. (2006), Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.; Nat. Chem. Biol., 2 474
-20°C
TARGET: HSP (Heat shock protein) -- PATHWAY: Bcl; Apoptosis inhibitor; p53; Autophagy -- RESEARCH AREA: Cell death; Ubiquitin/Proteasome; Stem cells; Cellular stress