www.mayflowerbio.com
Sales & Support: 314-485-5210

*

Pifithrin mu

Supplier:
Catalogue number:
10-1180-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
$45.00 Shipping is calculated in checkout

Hsp70 inhibitor / Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. Inhibits p53 binding to antiapoptotic proteins Bcl-xL and Bcl-2. Recues primary mouse thymocytes from P53-mediated apoptosis induced by radiation. Cell permeable.

Product Type:

Biochemicals & reagents

CAS Number:

64984-31-2

Alternative Names:

PES; NSC-303580

Reference:

1) Leu et al. (2009), The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53.; Mol. Cell, 36 15. / 2) Strom et al. (2006), Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.; Nat. Chem. Biol., 2 474

Storage Temperature:

-20°C

Additional Information:

TARGET: HSP (Heat shock protein) -- PATHWAY: Bcl; Apoptosis inhibitor; p53; Autophagy -- RESEARCH AREA: Cell death; Ubiquitin/Proteasome; Stem cells; Cellular stress