Teprenone
HSP70 inducer / Induces expression of HSP70 after various types of stimuli.1,2 Protects against visceral adipocity and insulin resistance in high fat fed mice.3 Displays protective effects via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats.4
Biochemicals & reagents
6809-52-5
Geranylgeranylacetone; GGA
1) Kamal and Omran (2013) The role of heat shock protein 70 induced by geranylgeranylacetone in carbon tetrachloride-exposed adult rat testes; Pathophysiology 20 139 2) Lennikov et al. (2013) Induction of heat chock protein 70 ameliorates ultraviolet-induced photokeratitis in mice; Int.J.Mol.Sci. 14 2175 3) Adache et al. (2010) An acyclic polyisoprenoid derivative, geranylgeranylacetone, protects against visceral adiposity and insulin resistance in high fat fed mice; Am.J.Physiol.Endocrinol.Metab. 299 E764 4) Marunouchi et al. (2014) Protective effect pf geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats; Eur.J.Pharmacol. 730 140
-20°C
TARGET: HSP (Heat shock protein) -- PATHWAY: Fatty acid metabolism; Posttranslational modification; Autophagy -- RESEARCH AREA: Ubiquitin/Proteasome; Cell death; Cellular stress -- DISEASE AREA: Diabetes; Heart disease