Simvastatin
HMG-CoA reductase inhibitor / A synthetic analog of lovastatin. Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase1,2. Induces apoptosis in various cell lines. Causes cell cycle arrest in early G1 phase. Clinically useful antilipemic agent3.
Biochemicals & reagents
79902-63-9
Mevinolin
1) Merck 14:8539 / 2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated; Cell, 57 1167 / 3) Ose et al. (2000), Lipid-altering efficacy and safety of simvastatin 80 mg/day: long-term experience in a large group of patients with hypercholesterolemia. World Wide Expanded Dose Simvastatin Study Group, Clin. Cardiol. 23 39
-20°C
TARGET: HMG-CoA reductase -- PATHWAY: Cholesterol metabolism; Cell cycle; Apoptosis inducer -- RESEARCH AREA: Cell death -- DISEASE AREA: Atherosclerosis; Heart disease